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Pepsin / ˈ p ɛ p s ɪ n / is an endopeptidase that breaks down proteins into smaller peptides and amino acids. It is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin is an aspartic protease, using a catalytic aspartate in its active site. [2]
Digestive enzymes take part in the chemical process of digestion, which follows the mechanical process of digestion. Food consists of macromolecules of proteins, carbohydrates, and fats that need to be broken down chemically by digestive enzymes in the mouth, stomach, pancreas, and duodenum, before being able to be absorbed into the bloodstream ...
A prime example of this is pepsin, which is secreted in the stomach by chief cells. Pepsin in its secreted form is inactive . However, once it reaches the gastric lumen it becomes activated into pepsin by the high H+ concentration, becoming an enzyme vital to digestion. The release of the enzymes is regulated by neural, hormonal, or paracrine ...
Protein catabolism is a key function of digestion process. Protein catabolism often begins with pepsin, which converts proteins into polypeptides. These polypeptides are then further degraded. In humans, the pancreatic proteases include trypsin, chymotrypsin, and other enzymes. In the intestine, the small peptides are broken down into amino ...
This releases carbohydrates, protein, fat, and various vitamins and minerals for absorption into the body. Overview of vertebrate digestion In most vertebrates , digestion is a multistage process in the digestive system, starting from ingestion of raw materials, most often other organisms.
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of pancreatic digestive enzymes.
The three major classes of nutrients that undergo digestion are proteins, lipids (fats) and carbohydrates: Proteins are degraded into small peptides and amino acids before absorption. [19] Chemical breakdown begins in the stomach and continues in the small intestine.
Its main function is to absorb the products of digestion (including carbohydrates, proteins, lipids, and vitamins) into the bloodstream. There are three major divisions: Duodenum : A short structure (about 20–25 cm long [ 18 ] ) that receives chyme from the stomach, together with pancreatic juice containing digestive enzymes and bile from the ...