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Arginine/lysine, sold under the brand name Lysakare, is a fixed-dose combination medication used to protect the kidneys from radiation damage during cancer treatment with a radioactive medicine called lutetium (177 Lu) oxodotreotide. [2] It contains L-arginine hydrochloride and L-lysine hydrochloride. [2]
[6] [7] [8] Whilst approaches at modifying the latter with oral supplements of folic acid were strongly suggested, studies have shown this fails to give any clinical benefit and suggested that B vitamins might instead increase some cardiovascular risks. [9] [10] [11] Direct alteration of ADMA levels with supplements of L-arginine have been ...
L-arginine is recognized as safe (GRAS-status) at intakes of up to 20 grams per day. [51] L-arginine is found in many foods, such as fish, poultry, and dairy products, and is used as a dietary supplement. [52] It may interact with various prescription drugs and herbal supplements. [52]
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Substitutions are made at GLP positions 8 and 34 (semaglutide positions 2 and 28), where alanine and lysine are replaced by 2-aminoisobutyric acid and arginine, respectively. [44] The substitution of the alanine prevents chemical breakdown by dipeptidyl peptidase-4 . [ 45 ]
l-Arginine ethyl ester is a white powder quickly soluble in hot water. It has a characteristically bad and bitter taste, thus before drinking it is recommended to mix the powder with a strongly flavored beverage or citrus juice. [dubious – discuss] Arginine ethyl ester falls under the category of protected aminoacids.
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