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Significant mitral valve regurgitation has a prevalence of approximately 2% of the population, affecting males and females equally. [26] It is one of the two most common valvular heart diseases in the elderly, [27] and the commonest type of valvular heart disease in low and middle income countries. [3]
In an Indian hospital between 2004 and 2005, 4 of 24 endocarditis patients failed to demonstrate classic vegetations. All had rheumatic heart disease (RHD) and presented with prolonged fever. All had severe eccentric mitral regurgitation (MR). (One had severe aortic regurgitation (AR) also.) One had flail posterior mitral leaflet (PML). [34]
Patients with mitral valve regurgitation typically have a holosystolic murmur, meaning it lasts for the duration of systole. Now even though we said that left-sided heart failure can cause mitral regurgitation, it also goes the other way, mitral regurgitation can be a cause of left-sided heart failure.
By far the most serious adverse event is the occurrence of acute severe mitral regurgitation. Severe mitral regurgitation usually results from a tear in one of the valve leaflets or the subvalvular apparatus. It can lead to pulmonary edema and hemodynamic compromise, necessitating urgent surgical mitral valve replacement. [citation needed]
This heart sound when present in a child or young adult implies the presence of a supple ventricle that can undergo rapid filling. Conversely, when heard in a middle-aged or older adult, an S 3 is often a sign of disease, indicating increased ventricular filling due to congestive heart failure or severe mitral or tricuspid regurgitation. [6]
This test can also show leaflet calcification and the pressure gradient over the mitral valve. [32] Severe mitral stenosis is defined as a mitral valve area <1.5 cm 2. [8] Progressive mitral stenosis has a normal valve area but will have increased flow velocity across the mitral valve. [8]
Aortic regurgitation: the backflow of blood from the aorta into the left ventricle, owing to insufficiency of the aortic semilunar valve; it may be chronic or acute. Mitral regurgitation: the backflow of blood from the left ventricle into the left atrium, owing to insufficiency of the mitral valve; it may be acute or chronic, and is usually due ...
Mitral valve prolapse: This is the most common cause of late systolic murmurs. It can be heard best over the apex of the heart, usually preceded by clicks. The most common cause of mitral valve prolapse is "floppy" valve (Barlow's) syndrome. If the prolapse becomes severe enough, mitral regurgitation may occur.
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