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The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Nicotine withdrawal is a group of symptoms that occur in the first few weeks after stopping or decreasing use of nicotine. Symptoms include intense cravings for nicotine, anger or irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating. [1][2][3] Withdrawal symptoms make ...
Nicotine use for tobacco cessation has few contraindications. [71] It is not known whether nicotine replacement therapy is effective for smoking cessation in adolescents, as of 2014. [72] It is therefore not recommended to adolescents. [73] It is not safe to use nicotine during pregnancy or breastfeeding, although it is safer than smoking.
Nicotine may be safer than nicotine plus the other chemicals found in cigarettes and vapes, but on its own, nicotine has been associated with detrimental health effects as well, says Bhatnagar.
Tobacco harm reduction (THR) is a public health strategy to lower the health risks to individuals and wider society associated with using tobacco products. It is an example of the concept of harm reduction, a strategy for dealing with the use of drugs. Tobacco smoking is widely acknowledged as a leading cause of illness and death, [1] and ...
Nicotine replacement therapy (NRT) is a medically approved way to treat people with tobacco use disorder by taking nicotine through means other than tobacco. [ 6 ] It is used to help with quitting smoking or stopping chewing tobacco. [ 1 ][ 7 ] It increases the chance of quitting tobacco smoking by about 55%. [ 8 ]
Nicotinic agonist. A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine. Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine. [1]
It is a type of nicotine replacement therapy(NRT) used alone or in combination with other pharmacotherapy for smoking cessationand for quitting smokeless tobacco. [2] Nicotine gum is available via general, pharmaceutical, and online sales without the need for a prescription. Flavor options range from mint and cinnamon to various fruit flavors ...
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