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Amlodipine works partly by vasodilation (relaxing the arteries and increasing their diameter). [10] It is a long-acting calcium channel blocker of the dihydropyridine type. [10] Amlodipine was patented in 1982, and approved for medical use in 1990. [12] It is on the World Health Organization's List of Essential Medicines. [13]
"The most common causes of palpitations include cardiac disorders, medical conditions including endocrine and metabolic abnormalities, psychiatric disorders, medication effects and drug or other ...
This can progress to the heart stopping altogether. [2] Some CCBs can also cause a fast heart rate as a result of the low blood pressure. [4] Other symptoms may include nausea, vomiting, sleepiness, and shortness of breath. [2] Symptoms usually occur in the first six hours but with some forms of the medication may not start for 24 hours or more ...
A number of drugs that cause QT prolongation does not directly block hERG, but reduces the trafficking of the mature protein to the surface of the cell. This includes probucol , which appears to enhance the intercellular degradation of hERG; and several cardiac glycosides , which reduces trafficking due to decreased intracellular potassium.
Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. [7] It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. [1]
[1] [5] People with TIC may have symptoms associated with heart failure (e.g. shortness of breath or ankle swelling) and/or symptoms related to the tachycardia or arrhythmia (e.g. palpitations). [1] [2] Though atrial fibrillation is the most common cause of TIC, several tachycardias and arrhythmias have been associated with the disease. [5] [1]
Other causes of angina include abnormal heart rhythms, heart failure and, less commonly, anemia. [4] The term derives from Latin angere 'to strangle' and pectus 'chest', and can therefore be translated as "a strangling feeling in the chest". An urgent medical assessment is suggested to rule out serious medical conditions. [5]
Arrhythmias also cause chest pain and shortness of breath. [citation needed] Some arrhythmias do not cause symptoms and are not associated with increased mortality. However, some asymptomatic arrhythmias are associated with adverse events. Examples include a higher risk of blood clotting within the heart and a higher risk of insufficient blood ...