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Bioavailability is likely linear and dose-proportional over a dose range of 150 to 200 mg. [5] Concomitant intake of sertraline with food slightly increases sertraline peak levels and total exposure. [5] There is an approximate 2-fold accumulation of sertraline with continuous administration and steady-state levels are reached within one week. [5]
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug or other substances may lead to severe psychological or physical dependence. The complete list of Schedule II substances is as follows.
Most importantly, zimelidine did not come with the adverse effect profile as the TCAs and therefore it became the template for the second generation SSRIs. [6] Zimelidine was the first SSRI to be marketed, but several cases of Guillain–Barré syndrome were associated with the use of the drug which led to withdrawal from the market in 1983.
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Diet with exercise may reduce the risk of caesarean section, having a large baby and having a baby with serious breathing problems. [24] Diet and exercise help pregnant women not gain too much weight during pregnancy when compared with giving the women no help to control weight gain or routine care (usually one session in the pregnancy).
Intrauterine growth restriction (IUGR), or fetal growth restriction, is the poor growth of a fetus while in the womb during pregnancy.IUGR is defined by clinical features of malnutrition and evidence of reduced growth regardless of an infant's birth weight percentile. [5]
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]