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Those that block beta-2-adrenergic receptors reduce blood pressure through increased relaxation of smooth muscle. [33] Alpha-blockers can block alpha-1 adrenergic receptors and/or alpha-2 adrenergic receptors. [34] Those that block alpha-1-adrenergic receptors on vascular smooth muscle cells prevent vasoconstriction. [34]
Finally, in drugs with both alpha and beta blocking properties, such as carvedilol and labetalol, interactions with other alpha or beta blockers can exaggerate a decrease in blood pressure. [2] Conversely, there are also drug interactions with carvedilol or labetalol in which blood pressure is increased unintentionally (such as with cough and ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
First generation alpha-1 blockers, like prazosin are not recommended to treat lower urinary tract symptoms because of their blood-pressure-lowering effect. Later generation drugs in this class are used for this purpose. [1] [9] In some cases alpha-1 blockers have been used in combined therapy with 5α-reductase inhibitors.
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
As alpha 1 blocker will dilate blood vessels, it lowers the blood pressure. [3] Thus, it contraindicate to patients with a history of orthostatic hypotension and in current use of phosphodiesterase inhibitors. [3] Moreover, alpha 1 blocker should not be given to patients with heart failure since it expands blood volume. [13]
What is high blood pressure? The AHA defines a normal blood pressure reading as less than 120 over 80. Elevated blood pressure is 120-129 and less than 80. Stage one high blood pressure is 130-139 ...
Alpha 1 blockers cause vasodilation by relaxing smooth muscles that control blood vessel diameter, leading to lower blood pressure. [1] FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia.
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