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Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
The sequestra are surrounded by sclerotic bone which is relatively avascular (without a blood supply). Within the bone itself, the haversian canals become blocked with scar tissue, and the bone becomes surrounded by thickened periosteum. [citation needed] Due to the avascular nature of this bone, antibiotics which travel to sites of infection ...
Bone cells. LEMD3 (protein) referred also as MAN1, is an important protein in inner nuclear membrane. LEMD3 gene gives instructions for producing protein that controls signaling for transforming growth factor-beta. LEMD3 gene helps in the bone morphogenic protein pathway; Both of the above pathways help grow new bone cells
Condensing osteitis, also known as focal sclerosing osteomyelitis, is a rare periapical inflammatory condition characterized by the formation of sclerotic bone near the roots of premolars and molars. This condition arises as a response to dental infections, such as periapical pulp inflammation or low-intensity trauma.
Lichen sclerosus, an inflammatory skin disease that most often affects the vulva and the penis. Multiple sclerosis, or focal sclerosis, [2] is a central nervous system disease which affects coordination. Osteosclerosis, a condition where the bone density is significantly increased, resulting in decreased lucency on radiographs.
Morphea is a form of scleroderma that mainly involves isolated patches of hardened skin on the face, hands, and feet, or anywhere else on the body, usually with no internal organ involvement. [1] However, in Deep Morphea inflammation and sclerosis can be found in the deep dermis , panniculus , fascia , superficial muscle and bone.
This study found that 25% of participants, with a mean age of 38 years (ranging from 14 to 59 years), had Monckeberg's calcification without any cardiovascular disease risk factors. This indicates that Monckeberg's calcification may develop early in life, potentially due to abnormal osteogenic differentiation of vascular progenitor cells .