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Aplastic anemia is a rare, noncancerous disorder in which the blood marrow is unable to adequately produce blood cells required for survival. [44] [45] It is estimated that the incidence of aplastic anemia is 0.7–4.1 cases per million people worldwide, with the prevalence between men and women being approximately equal. [46]
McFall v. Shimp, 10 Pa. D. & C. 3d 90 (July 26, 1978), was an Allegheny County, Pennsylvania, court case. The court ruled that it is unacceptable to force another person to donate body parts, even in a situation of medical necessity.
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare autosomal recessive bone marrow failure syndrome characterized by severe thrombocytopenia, which can progress to aplastic anemia and leukemia. [4] CAMT usually manifests as thrombocytopenia in the initial month of life or in the fetal phase.
Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922. [1]
Severe aplastic anemia is a rare disease in which the body is suddenly unable to produce new blood cells and platelets. Its victims have no effective immune system and must be protected from infection. DeVita was admitted to the National Institutes of Health Clinical Center.
While acquired aplastic anemia with an unknown cause is rare, it is commonly permanent and life-threatening as half of those with this condition die within the first six months. [ 10 ] The prevalence of bone marrow failure is over three times higher in Japan and East Asia than in the United States and Europe. [ 10 ]
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This is termed "aplastic crisis" (also called reticulocytopenia). It is treated with blood transfusion. Parvovirus B19 is a cause of chronic anemia in individuals with immunodeficiency, receiving immunosuppressive therapy or with HIV infection. Treatment with intravenous immunoglobulin usually resolves the anemia although relapse can occur.