Search results
Results from the WOW.Com Content Network
For example, the CHOP regimen consists of cyclophosphamide, doxorubicin, vincristine and prednisone. Besides chemotherapy, medical oncology ( pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy).
1. Cytotoxic antineoplastics: 1.01 Nucleoside analogues: Azacitidine: SC, IV: DNA methyltransferase inhibitor and incorporates itself into RNA, hence inhibiting gene expression. [6] Myelodysplastic syndromes, acute myeloid leukaemia and chronic myeloid leukaemia: Myelosuppression, kidney failure (uncommon/rare), renal tubular acidosis and ...
Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence. [ 2 ] In total, these drugs can cause a combination of more than 40 specific side effects which include neurotoxicity , which is manifested by peripheral neuropathies including polyneuropathy .
Busulfan is an example of a dialkylating agent: it is the methanesulfonate diester of 1,4-butanediol. Methanesulfonate can be eliminated as a leaving group. Both ends of the molecule can be attacked by DNA bases, producing a butylene crosslink between two different bases. Monoalkylating agents can react only with one 7-N of guanine.
Palliative chemotherapy Palliative chemotherapy is used to control (but not cure) the cancer in settings in which the cancer has spread beyond the breast and localized lymph nodes. See metastatic breast cancer. Combined therapies These combine, for example, non-drug treatments with localized chemotherapy to limit toxicity and achieve better ...
Trastuzumab emtansine (Kadcyla) is an antibody conjugated to a synthetic derivative of the cytotoxic principle of the Ethiopian plant Maytenus ovatus. It used to treat breast cancer. [10] Mappia foetida. Some of the research has been showed that it has an effective anticancer property against breast cancer
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
DON is a cytotoxic inhibitor of many enzymes of nucleotide synthesis. It could be shown in vitro that DON treatment led to apoptosis , or programmed cell death. Different pathways were investigated; it could be shown that the inner mitochondrial membrane was damaged, [ 14 ] and that single strand DNA breaks occurred. [ 15 ]