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  2. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]

  4. Obesity in pets - Wikipedia

    en.wikipedia.org/wiki/Obesity_in_pets

    Achieving weight loss in cats and dogs is challenging, and failure to lose weight is common. [17] If the animals themselves cannot control their own calorie intake, it is recommended that pet owners control the food amount given. Guidelines exist on energy allowances for animals of a given body weight. [18]

  5. 25 of the very best deals from Nordstrom's Half-Yearly Sale ...

    www.aol.com/lifestyle/the-very-best-deals-from...

    One of the best post-Christmas sales we look forward to every year is Nordstrom's Half-Yearly Sale, which typically kicks off the day after Christmas and lasts for a couple of weeks.Ring in the ...

  6. Skin conditions in dogs: Symptoms, causes, and how to help - AOL

    www.aol.com/skin-conditions-dogs-symptoms-causes...

    The dog then causes further trauma to the skin by itching and rubbing at the area, leading to a secondary bacterial infection." Acute moist dermatitis: Symptoms A patch of moist, inflamed skin ...

  7. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  8. Does My Dog Need the Parvo Vaccine if He Recovered From the ...

    www.aol.com/does-dog-parvo-vaccine-recovered...

    The microbiome of dogs fed whole food is more diverse than dogs fed dry food, and this may be important in controlling diarrhea in a dog that has recovered from a parvo infection.

  9. Anticoagulant - Wikipedia

    en.wikipedia.org/wiki/Anticoagulant

    An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.