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Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. [4] They are often used for the treatment of hypertension and edema secondary to congestive heart failure , liver cirrhosis , or chronic kidney disease .
Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim. [1] [2] As of 2015 it was available as a generic in some Asian countries. [3] Azosemide has been found as an adulterant in ketamine. [4]
Metolazone and a loop diuretic will synergistically enhance diuresis over the use of either agent alone. Using this combination, diuretic effects will occur at two different segments of the nephron; namely, the loop diuretic will act at the loop of Henle, and metolazone will act at the distal convoluted tubule. Metolazone is frequently ...
Pages in category "Loop diuretics" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. ...
Loop diuretics, such as furosemide, inhibit the body's ability to reabsorb sodium at the ascending loop in the nephron, which leads to an excretion of water in the urine, whereas water normally follows sodium back into the extracellular fluid. Other examples of high-ceiling loop diuretics include ethacrynic acid and torasemide. [citation needed]
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Furosemide blocks NaCl reabsorption mediated by the NKCC2 at the ascending loop of henle, which leads to increased renin release. Excluding loop diuretic use, the usual situation that causes a reduction in reabsorption of NaCl via the NKCC2 at the macula densa (DCT) is a low tubular lumen concentration of NaCl due to low GFR.
Partisan control is on the line in the upcoming Wisconsin Supreme Court election. The state’s high court currently has a 4-3 liberal tilt, but Justice Ann Walsh Bradley’s retirement will bring ...