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Available transdermal estradiol patches in the United States [1] [2] [a] Brand name Dose (µg/day) DOA (d) Size [b] [c] (cm 2) Levels (pg/mL) Intro. Alora [3] [4] 25, 50, 75, 100 3–4 9, 18, 27, 36 43–144 1996 Climara [d] [5] [6] 25, 37.5, 50, 60, 75, 100 7 6.5, 9.375, 12.5, 15, 18.75, 25 17–174 1994 Climara Pro [e] [7] [8] E2 (45)
Estrogen dosages for menopausal hormone therapy; Route/form Estrogen Low Standard High Oral: Estradiol: 0.5–1 mg/day: 1–2 mg/day: 2–4 mg/day Estradiol valerate: 0.5–1 mg/day: 1–2 mg/day: 2–4 mg/day Estradiol acetate: 0.45–0.9 mg/day: 0.9–1.8 mg/day: 1.8–3.6 mg/day Conjugated estrogens: 0.3–0.45 mg/day: 0.625 mg/day: 0.9–1. ...
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Combined contraceptive patch [7] 120-150 μg of norelgestromin and 20-35 μg ethinyl estradiol daily [20] [21] [22] New patch used once a week, after 3 weeks patch is not worn to allow for withdrawal bleeding [19] Combined contraceptive vaginal ring [7] 120-150 μg etonogestrel and 13-15 μg ethinyl estradiol daily [20] [23] [24]
Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol dipropionate: Agofollin: Estrogen: IM, SC: 2–10 mg/wk or 5 ...
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[213] [97] [12] [10] Estradiol patches delivering a daily dosage of 0.05 mg (50 μg) achieve mean estradiol and estrone levels of 30 to 65 pg/mL and 40 to 45 pg/mL, respectively, while a daily dosage of 0.1 mg (100 μg) attains respective mean levels of 50 to 90 pg/mL and 30 to 65 pg/mL of estradiol and estrone. [15]