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Medical use of arsenic trioxide refers to the use of arsenic trioxide (Latin: Arsenum trioxydatum, [1] also known as "arsenic") as an chemotherapeutic agent in the treatment of acute promyelocytic leukemia. Arsenic trioxide has orphan drug status [2] and is available as the pharmaceutical preparation Trisenox.
Arsenic trioxide is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia whose acute promyelocytic leukemia is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression; and for induction of remission and consolidation in patients with acute promyelocytic leukemia who are refractory to, or ...
Arsenic trioxide (As 2 O 3) inhibits cell growth and induces apoptosis (programmed cell death) in certain types of cancer cells, [23] which are normally immortal and can multiply without limit. In combination with all-trans retinoic acid , it is FDA-approved as first-line treatment for promyelocytic leukemia .
Nearly one in five new cervical cancers diagnosed from 2009 to 2018 were in women 65 and older, according to a new UC Davis study.But what has experts concerned is that, according to the study ...
Zhang Tingdong (Chinese: 张亭栋; pinyin: Zhāng Tíngdòng; born on November 8, 1932) is a Chinese medical scientist, pharmaceutical chemist, and educator at Harbin Medical University, 1st affiliated Hospital, and is best known for discovering of using arsenic trioxide to treat leukemia, which is regarded as a significant breakthrough of anti-leukemia medicine in the 20th Century and ...
Non-small cell lung cancer, oesophageal cancer, uterine cervical cancer, head and neck cancer and urothelial cancer: Nephrotoxicity, myelosuppression and nausea and vomiting (30-90%). Oxaliplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific. Colorectal cancer, oesophageal cancer and gastric cancer
Satirical cartoon by Honoré Daumier of a chemist giving a public demonstration of arsenic, 1841. In the Victorian era, women would eat "arsenic" ("white arsenic" or arsenic trioxide) mixed with vinegar and chalk to improve the complexion of their faces, making their skin paler (to show they did not work in the fields). [70]
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