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Mitophagy is the selective degradation of mitochondria by autophagy.It often occurs to defective mitochondria following damage or stress. The process of mitophagy was first described in 1915 by Margaret Reed Lewis and Warren Harmon Lewis. [1]
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are found in every cell of the human body except red blood cells. They convert the energy of food molecules into the ATP that powers most cell functions.
Mitochondrial toxicity is a condition in which the mitochondria of a body's cells become damaged or decline significantly in number; it occurs as a side effect of certain antiretroviral drugs used to treat human immunodeficiency virus, or HIV.
A novel drug molecule that activates a key protein in the brain that cleans up and recycles damaged mitochondria may offer hope for young Parkinson's patients, a new study suggests.
Mitochondrial dysfunction causes intestinal tissue damage For this study, researchers used a mouse model where a specific gene segment was deleted, disrupting their mitochondrial function.
Boosting mitochondrial health may help delay the damage. New research in worm models suggests that natural aging processes, as well as toxic beta-amyloid may drive the accumulation of harmful ...
Normally, these mitochondrial components are sequestered from the rest of the cell but are released following mitochondrial membrane permeabilization during apoptosis or passively after mitochondrial damage. However, mitochondria also play an active role in innate immunity, releasing mtDNA in response to metabolic cues. [74]
Mitochondrial myopathies are types of myopathies associated with mitochondrial disease. [1] Adenosine triphosphate (), the chemical used to provide energy for the cell, cannot be produced sufficiently by oxidative phosphorylation when the mitochondrion is either damaged or missing necessary enzymes or transport proteins.