Search results
Results from the WOW.Com Content Network
They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS). In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues [ 6 ] including the kidney, liver, GI tract, brain, and skeletal muscle.
Mitochondrial uncoupling protein 3 (UCP3) is a members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and transfer of protons from the outer to the inner mitochondrial membrane, reducing the mitochondrial membrane potential in mammalian cells.
Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter.An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.
UCP5 controls homeostasis by increasing ATP synthesis, mitochondrial polarization, and the prevention of apoptosis. It also maintains the potential of the mitochondrial membrane and lessens oxidative stress against 1-methyl-4-phenylpyridinium MPP+ and dopamine toxicity in SH-SY5Y cells.
74011 Ensembl ENSG00000153291 ENSMUSG00000023912 UniProt O95847 Q9D6D0 RefSeq (mRNA) NM_001204051 NM_001204052 NM_004277 NM_028711 NM_001357122 NM_001357123 RefSeq (protein) NP_001190980 NP_001190981 NP_004268 NP_082987 NP_001344051 NP_001344052 Location (UCSC) Chr 6: 46.65 – 46.68 Mb Chr 17: 43.64 – 43.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial uncoupling ...
In essence, the Goldman formula expresses the membrane potential as a weighted average of the reversal potentials for the individual ion types, weighted by permeability. (Although the membrane potential changes about 100 mV during an action potential, the concentrations of ions inside and outside the cell do not change significantly.
22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
The calcium is taken up into the matrix by the mitochondrial calcium uniporter on the inner mitochondrial membrane. [61] It is primarily driven by the mitochondrial membrane potential. [55] Release of this calcium back into the cell's interior can occur via a sodium-calcium exchange protein or via "calcium-induced-calcium-release" pathways. [61]