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The clinical manifestations are highly variable, ranging from partial virilisation and ambiguous genitalia at birth, to patients with completely male or female gonads. Most individuals with this karyotype have apparently normal male genitalia , and a minority have female genitalia , with a significant number of individuals showing genital ...
Transgender people who were medically assigned female at birth sometimes elect to take hormone replacement therapy. This process causes virilization by inducing many of the effects of a typically male puberty. Many of these effects are permanent, but some effects can be reversed if the transgender individual stops or pauses their medical treatment.
Sexual maturation disorder, along with ego-dystonic sexual orientation and sexual relationship disorder, was introduced to the ICD in 1990, replacing the ICD-9 diagnosis of homosexuality. [4] The following note was applied to the entirety of part F66, the section in which these three diagnoses appeared: "Sexual orientation by itself is not to ...
Complete androgen insensitivity syndrome causes a genetic male to have a vagina (often incompletely developed, nearly always blind-ending), breasts, and a clitoris; people with this form are raised as females. [25] Aphallia – a rare condition where a XY male is born without a penis. As of 2017, only 100 cases have been reported in literature ...
In 5α-Reductase 2 deficiency, individuals are born with normal female genitalia, however, during puberty, male differentiation and spermatogenesis occurs. Partial genital undermasculinization can occur if the body has a partial resistance to androgens , or if genital development is blocked, undermasculization can also be induced by certain ...
During puberty, a male's erect penis becomes capable of ejaculating semen and impregnating a female. [26] [27] A male's first ejaculation is an important milestone in his development. [28] On average, a male's first ejaculation occurs at age 13. [29] Ejaculation sometimes occurs during sleep; this phenomenon is known as a nocturnal emission. [25]
Male pseudohermaphroditism refers to an individual with testicles and external genitalia resembling those of a female. [5] [6] In some cases, external sex organs associated with pseudohermaphroditism appear intermediate between a typical clitoris and penis. Thus, pseudohermaphroditism is sometimes not identified until puberty or adulthood.
Aromatase deficiency is a rare condition characterized by extremely low levels or complete absence of the enzyme aromatase activity in the body. [2] It is an autosomal recessive disease resulting from various mutations of gene CYP19 (P450arom) which can lead to ambiguous genitalia and delayed puberty in females, continued linear growth into adulthood and osteoporosis in males and virilization ...