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While the high-dose chemotherapy and bone marrow transplant treatment is known for its impact on breast cancer, the treatment is presently used to treat other types of cancer, including testicular cancer, neuroblastoma, multiple myeloma, and various types of leukemias and lymphomas, like Hodgkin and non-Hodgkin Lymphoma.
The first physician to perform a successful human bone-marrow transplant on a disease other than cancer was Robert A. Good at the University of Minnesota in 1968. [74] In 1975, John Kersey, also of the University of Minnesota, performed the first successful bone-marrow transplant to cure lymphoma.
CBV is usually given in high doses to patients who have relapsed or who have refractory disease and cannot benefit from standard chemotherapy. Since a patient's bone marrow is virtually guaranteed not to survive a course of CBV, the receiving patient must receive a transplant (allogeneic or autologous, depending on his or her condition) of stem ...
Once the chemotherapy is completed, the stored stem cells are infused back into the patient's body. This procedure helps to restore the bone marrow and support the recovery of blood cells. ASCT has allowed for the administration of HDC, with improvements in supportive care reducing associated morbidity and mortality. [1] [2]
Chemotherapy drugs are also used in conditioning regimens prior to bone marrow transplant (hematopoietic stem cell transplant). Conditioning regimens are used to suppress the recipient's immune system in order to allow a transplant to engraft.
Later in June, Whitney underwent a lifesaving bone marrow transplant. Two months later, Fivecoat had a double mastectomy. Amid their respective treatments, both grandmother and granddaughter lost ...
It is a complication of high-dose chemotherapy given before a bone marrow transplant and/or excessive exposure to hepatotoxic pyrrolizidine alkaloids. It is classically marked by weight gain due to fluid retention , increased liver size , and raised levels of bilirubin in the blood. [ 1 ]
before a transplant, such as a kidney or bone marrow transplant. before cardiac valve replacement. ... to treat an infection before a person receives chemotherapy or other cancer treatments.
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