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Transpulmonary pressure is the difference between the alveolar pressure and the intrapleural pressure in the pleural cavity. During human ventilation, air flows because of pressure gradients. P tp = P alv – P ip. Where P tp is transpulmonary pressure, P alv is alveolar pressure, and P ip is intrapleural pressure.
Intrapleural pressure depends on the ventilation phase, atmospheric pressure, and the volume of the intrapleural cavity. [2] At rest, there is a negative intrapleural pressure. This provides a transpulmonary pressure, causing the lungs to expand. If humans didn't maintain a slightly negative pressure even when exhaling, their lungs would ...
Dynamic compression of the airways results when intrapleural pressure equals or exceeds alveolar pressure, which causes dynamic collapsing of the lung airways. It is termed dynamic given the transpulmonary pressure (alveolar pressure − intrapleural pressure) varies based on factors including lung volume, compliance, resistance, existing pathologies, etc. [1]
Once air enters the pleural cavity, the intrapleural pressure increases, resulting in the difference between the intrapulmonary pressure and the intrapleural pressure (defined as the transpulmonary pressure) to equal zero, which cause the lungs to deflate in contrast to a normal transpulmonary pressure of ~4 mm Hg. [28]
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The pleural cavity, or pleural space (or sometimes intrapleural space), is the potential space between the pleurae of the pleural sac that surrounds each lung.A small amount of serous pleural fluid is maintained in the pleural cavity to enable lubrication between the membranes, and also to create a pressure gradient.
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