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  2. Ketamine-assisted psychotherapy - Wikipedia

    en.wikipedia.org/wiki/Ketamine-assisted...

    Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]

  3. Ketamine - Wikipedia

    en.wikipedia.org/wiki/Ketamine

    The discovery of antidepressive action of ketamine in 2000 [143] has been described as the single most important advance in the treatment of depression in more than 50 years. [61] [11] It has sparked interest in NMDA receptor antagonists for depression, [144] and has shifted the direction of antidepressant research and development. [145]

  4. Mixed anxiety–depressive disorder - Wikipedia

    en.wikipedia.org/wiki/Mixed_anxiety–depressive...

    The symptoms of anxiety and depression disorders can be very similar. A diagnosis of mixed anxiety–depressive disorder as opposed to a diagnosis of depression or an anxiety disorder can be difficult. Due to this, it has long been a struggle to find a singular set of criteria to use in the diagnosis of mixed-anxiety depressive disorder. [3]

  5. PDE4 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE4_inhibitor

    Consequently, PDE4 inhibitors have been investigated as treatments for a diverse group of different diseases, including central nervous system disorders such as major depressive disorder (clinical depression), anxiety disorders, schizophrenia, [7] [8] Parkinson's disease, [9] Alzheimer's disease, [10] multiple sclerosis, [11] attention deficit ...

  6. Anxiolytic - Wikipedia

    en.wikipedia.org/wiki/Anxiolytic

    SSRIs are beneficial in both acute response and long-term maintenance treatment for both depression and anxiety disorder. [16] SSRIs can increase anxiety initially due to negative feedback through the serotonergic autoreceptors; for this reason a concurrent benzodiazepine can be used until the anxiolytic effect of the SSRI occurs. [18]

  7. Amisulpride - Wikipedia

    en.wikipedia.org/wiki/Amisulpride

    Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...

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