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  2. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. [5] TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. [ 12 ]

  3. p53 upregulated modulator of apoptosis - Wikipedia

    en.wikipedia.org/wiki/P53_upregulated_modulator...

    Many cancers exhibit mutations in the p53 gene, but this mutation can only be detected through extensive DNA sequencing. Studies have shown that cells with p53 mutations have significantly lower levels of PUMA, making it a good candidate for a protein marker of p53 mutations, providing a simpler method for testing for p53 mutations.

  4. TP53BP1 - Wikipedia

    en.wikipedia.org/wiki/TP53BP1

    Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene. [ 5 ] [ 6 ] [ 7 ] Clinical significance

  5. Cancer biomarker - Wikipedia

    en.wikipedia.org/wiki/Cancer_biomarker

    While numerous challenges exist in translating biomarker research into the clinical space; a number of gene and protein based biomarkers have already been used at some point in patient care; including, AFP (liver cancer), BCR-ABL (chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125 ...

  6. HT-29 - Wikipedia

    en.wikipedia.org/wiki/HT-29

    Initially derived in 1964 by Jorgen Fogh from a 44-year-old Caucasian female, HT-29 cells form a tight monolayer while exhibiting similarity to enterocytes from the small intestine. HT-29 cells overproduce the p53 tumor antigen, but have a mutation in the p53 gene at position 273, resulting in a histidine replacing an arginine .

  7. Suicide gene - Wikipedia

    en.wikipedia.org/wiki/Suicide_gene

    In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.

  8. Survivin - Wikipedia

    en.wikipedia.org/wiki/Survivin

    This same effect was not seen in T47D cells that carry mutant inactive p53. [17] P53's normal function is to regulate genes that control apoptosis. As survivin is a known inhibitor of apoptosis, it can be implied that p53 repression of survivin is one mechanism by which cells can undergo apoptosis upon induction by apoptotic stimuli or signals.

  9. Caretaker gene - Wikipedia

    en.wikipedia.org/wiki/Caretaker_gene

    An example of one such gene is p53. Patients with Li-Fraumeni syndrome, for example, have mutations in the p53 gene that suggest caretaker function. p53 has an identified role, however, in regulating the cell cycle as well, which is an essential gatekeeper function. [3]

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