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Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
Resistant hypertension is defined as hypertension that remains above goal blood pressure in spite of using, at once, three antihypertensive medications belonging to different drug classes. Guidelines for treating resistant hypertension have been published in the UK [45] and US. [46]
The American Heart Association estimated the direct and indirect costs of high blood pressure in 2010 as $76.6 billion. [163] In the US 80% of people with hypertension are aware of their condition, 71% take some antihypertensive medication, but only 48% of people aware that they have hypertension adequately control it. [ 163 ]
The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. [ 3 ]
Without proper treatment, hypertension can lead to: Atherosclerosis (a buildup of plaque in your arteries) Stroke. Cardiovascular disease. Heart failure. Heart attack. Eye damage. Kidney failure ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Association between sleep duration and hypertension incidence: Systematic review and meta-analysis of cohort studies. PLoS 1 . Bedtime hypertension treatment improves cardiovascular risk reduction ...
[49] [56] According to the 2017 [57] American Heart Association blood pressure guidelines state that a systolic blood pressure of 130–139 mmHg with a diastolic pressure of 80–89 mmHg is "stage one hypertension". [49] For those with heart valve regurgitation, a change in its severity may be associated with a change in diastolic pressure.
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