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Speedball, powerball, or over and under [1] is the polydrug mixture of a stimulant with a depressant, usually an opioid.The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl.
The onset of heroin's effects depends upon the route of administration. Smoking is the fastest route of drug administration, although intravenous injection results in a quicker rise in blood concentration. [49] These are followed by suppository (anal or vaginal insertion), insufflation (snorting), and ingestion (swallowing).
people already stabilized on other opioids who have persistent swallowing problems and cannot tolerate other parenteral routes such as subcutaneous administration. people with moderate to severe kidney failure. [50] troublesome side effects of oral morphine, hydromorphone, or oxycodone. [51] [52]
Naloxone is an over-the-counter nasal-spray medication that can save an overdose victim by rapidly reversing the effects of fentanyl, heroin and other opioids. Doctors urge all people ...
Opioids have a high potential for addiction and have the ability to induce severe physical withdrawal symptoms upon cessation of frequent use. Heroin can be smoked, insufflated, or turned into a solution with water and injected. [5] Percocet is a prescription opioid containing oxycodone and acetaminophen.
Naloxone, commonly known as Narcan, is a medication used to reverse the effects of opioids and is often used during suspected opioid overdoses. Naloxone comes in either an injectable form or as a ...
Different drug classes have different side effects. Long-term medical conditions induced by opioid include infection, hyperalgesia, opioid-induced bowel syndrome, opioid-related leukoencephalopathy and opioid amnestic syndrome. [32] Misuse of prescribed opioids medications is associated with increased morbidity and mortality. [37]
Common side effects include ... more than 12 million people use opioid drugs ... chewing, snorting, or injecting the opioid impractical because of a change in its ...