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2. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

3. Rivaroxaban - Wikipedia

   en.wikipedia.org/wiki/Rivaroxaban

   Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity, which is a known complication of long-term linezolid use. [40] Studies found that neither rivaroxaban nor its metabolites have any antibiotic effect against Gram-positive bacteria.

4. Andexanet alfa - Wikipedia

   en.wikipedia.org/wiki/Andexanet_alfa

   Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

5. 14 Things That Might Be Causing Pain in Your Lower Left Abdomen

   www.aol.com/14-things-might-causing-pain...

   “It usually causes pain on the lower left side of your belly, and you might also have fever, nausea, or changes in your bowel habits.” Most cases are treated with rest, antibiotics, and ...

6. Cialis Side Effects: What to Expect (& How to Avoid Them) - AOL

   www.aol.com/cialis-side-effects-expect-avoid...

   Cialis has several common side effects, many of which also happen with other drugs used to treat ED, like sildenafil (generic Viagra®), vardenafil , and avanafil (Stendra®).

7. Bayer's patent for blood thinner Xarelto invalid, UK court rules

   www.aol.com/news/bayers-patent-blood-thinner...

   Bayer's patent covering its best-selling blood thinner Xarelto is invalid, London's High Court ruled on Friday in a blow to the German drugmaker. The company's blockbuster Xarelto drug generated ...

8. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

9. Rhino Pills for Men: What Are They? (And What Should ... - AOL

   www.aol.com/rhino-pills-men-instead-105700270.html

   While Viagra typically works for just a few hours, Rhino claims the effects of a single pill can last seven, nine, or even 14 days. Yikes. Rhino pills could illegally contain sildenafil.