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A pyridinecarboxylic acid is any member of a group of organic compounds which are monocarboxylic derivatives of pyridine. Pyridinecarboxylic acid comes in three isomers: Picolinic acid (2-pyridinecarboxylic acid) Nicotinic acid (3-pyridinecarboxylic acid), also known as Niacin; Isonicotinic acid (4-pyridinecarboxylic acid)
B(C 6 F 5) 3 forms a strong Lewis adduct with water, [5] which was shown to be a strong Brønsted acid having an acidity comparable to hydrochloric acid (in acetonitrile). [6] In consequence, even traces of moisture are able to deactivate B(C 6 F 5 ) 3 and remaining catalytic activity might only be due to the Brønsted acidity of the water adduct.
Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH) 2 where Ph is the phenyl group C 6 H 5 - and B(OH) 2 is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis.
Boronic acids are known to bind to active site serines and are part of inhibitors for porcine pancreatic lipase, [2] subtilisin [3] and the protease Kex2. [4] Furthermore, boronic acid derivatives constitute a class of inhibitors for human acyl-protein thioesterase 1 and 2, which are cancer drug targets within the Ras cycle. [5]
This protocol has proved useful in the cross-coupling of some notoriously unstable boronic acids, such as the 2-pyridine boronic acid. [ 16 ] [ 17 ] This ensures that the boronic acid concentration is low during the cross-coupling reaction, which in turn minimises the potential for side reactions.
Triphenylborane, often abbreviated to BPh 3 where Ph is the phenyl group C 6 H − 5 , is a chemical compound with the formula B(C 6 H 5 ) 3 . It is a white crystalline solid and is both air and moisture sensitive, slowly forming benzene and triphenylboroxine .
5-(3-Pyridinylmethyl)benzofurancarboxylic acid, is an achiral, organic molecule containing a pyridine ring and a carboxylic acid group. The compound is a member of the benzofurans and can be found in a variety of forms (free-base, sodium salt and hydrochloric acid salt) all of them variations of the carboxylic acid functionality. [2]
[5] B2pin2 and B2cat2. The boron atom of a boronic ester or acid is sp 2 hybridized possessing a vacant p orbital, enabling these groups to act as Lewis acids. The C–B bond of boronic acids and esters are slightly longer than typical C–C single bonds with a range of 1.55-1.59 Å.