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A circadian rhythm (/ s ər ˈ k eɪ d i ə n /), or circadian cycle, is a natural oscillation that repeats roughly every 24 hours. Circadian rhythms can refer to any process that originates within an organism (i.e., endogenous ) and responds to the environment (is entrained by the environment).
Neurons in an intact SCN show coordinated circadian rhythms in electrical activity. [23] Neurons isolated from the SCN have been shown to produce and sustain circadian rhythms in vitro, [24] suggesting that each individual neuron of the SCN can function as an independent circadian oscillator at the cellular level. [25]
In vertebrates, the master circadian clock is contained within the suprachiasmatic nucleus (SCN), a bilateral nerve cluster of about 20,000 neurons. [10] [11] The SCN itself is located in the hypothalamus, a small region of the brain situated directly above the optic chiasm, where it receives input from specialized photosensitive ganglion cells in the retina via the retinohypothalamic tract.
Any biological process in the body that repeats itself over a period of approximately 24 hours and maintains this rhythm in the absence of external stimuli is considered a circadian rhythm. [4] It is believed that the brain's suprachiasmatic nucleus (SCN), or internal pacemaker, is responsible for regulating the body's biological rhythms ...
A circadian rhythm is an entrainable, endogenous, biological activity that has a period of roughly twenty-four hours. This internal time-keeping mechanism is centralized in the suprachiasmatic nucleus (SCN) of humans, and allows for the internal physiological mechanisms underlying sleep and alertness to become synchronized to external environmental cues, like the light-dark cycle. [3]
Biological rhythms are endogenous; they persist even in the absence of environmental cues as they are driven by an internal mechanism, the circadian clock being the best characterized. Of the several possible cues, known as zeitgebers (German for 'time-givers'), which can contribute to entrainment of the circadian clock, light has the greatest ...
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PER1 is rhythmically transcribed in the SCN, keeping a period of approximately 24 hours. This rhythm is sustained in constant darkness, and can also be entrained to changing light cycles. [5] PER1 is involved in generating circadian rhythms in the SCN, and also has an effect on other oscillations throughout the body.