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Gromeier re-engineered the polio virus by removing a key genetic sequence. The virus can't survive this way, so he repaired the damaged with a harmless bit of cold virus. The new, modified virus, could no longer cause paralysis or death because it couldn't reproduce in normal cells. However, in a cancerous environment, this is still possible.
PVSRIPO, or PVS-RIPO, is the name of a modified polio virus that has recently shown promise for treating cancer. It is the focus of clinical trials being conducted at Duke University. [1] PVS-RIPO consists of a genetically modified nonpathogenic version of the oral poliovirus Sabin type 1.
Paralytic poliomyelitis occurs in less than 1% of poliovirus infections. Paralytic disease occurs when the virus enters the central nervous system (CNS) and replicates in motor neurons within the spinal cord, brain stem, or motor cortex, resulting in the selective destruction of motor neurons leading to temporary or permanent paralysis.
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
A virus that affects nerves in the spinal cord or brain stem causes polio. ... There was an increase in people over the age of 10 getting the virus, too. Treatments for polio included hot wool and ...
A few could contract meningitis if the polio virus attacks the covering of the spinal cord or brain. Polio is fatal for 2%-10% of those paralyzed or between 1 in 2,000 to 1 in 10,000 of those ...
But after the polio virus was found in wastewater in New York recently, ... when it affects the brain or spinal cord. “A small proportion of people with polio can have devastating neurologic ...
In 1961, SV40 was found to cause tumors in rodents. [36] More recently, the virus was found in certain forms of cancer in humans, for instance brain and bone tumors, pleural and peritoneal mesothelioma, and some types of non-Hodgkin lymphoma. [37] [38] However, SV40 has not been determined to cause these cancers. [39]