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The toxin aflatoxin from certain Aspergillus species of fungi is a carcinogen and aids carcinogenesis of hepatocellular cancer by building up in the liver. The combined high prevalence of rates of aflatoxin and hepatitis B in settings such as China and West Africa has led to relatively high rates of hepatocellular carcinoma in these regions ...
Most of the research on hepatocellular carcinoma in the United States can be attributed to El-Serag, who has published more than 300 scholarly papers on the subject. Dr. El-Serag also has become a leading expert on chronic liver disease and gastroesophageal reflux disease.
Estimates based on most recent data suggest that each year there are 841,000 new liver cancer diagnoses and 782,000 deaths across the globe. [55] Liver cancer is the most common cancer in Egypt, the Gambia, Guinea, Mongolia, Cambodia, and Vietnam. [55] In terms of gender breakdown, globally liver cancer is more common in men than in women. [43 ...
Hepatocellular adenomas (also called hepatocellular adenoma) are rare benign liver tumors made up of hepatocytes, [2] with estimates indicating hepatocellular adenomas make up 2% of liver tumors. [7] They are most common in women using contraceptives or hormone replacement therapies containing estrogen , women who are pregnant, or people mis ...
He published more than 1,000 scientific papers, from seminal research linking secondhand smoke (SHS) from cigarettes with increased susceptibility to risk for lung cancer, and hepatitis B virus and tobacco smoking with increased risk of primary liver cancer (hepatocellular carcinoma), to findings documenting that surgically induced and early ...
Harris has made many major discoveries in cancer research. One of the most notable is his seminal work describing the first-known molecular link between an environmental carcinogen, aflatoxin B1, and a specific mutation at codon 249 of the p53-encoding TP53 gene in hepatocellular carcinoma (Nature 350:427, 1991 and web of science). [6]
Fibrolamellar carcinoma (FLC) is a rare form of carcinoma that typically affects young adults and is characterized, under the microscope, by laminated fibrous layers interspersed between the tumor cells. [1] It has been estimated that 200 new cases are diagnosed worldwide each year. [2]
Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. [1] These cells are epithelial in morphology, have a modal chromosome number of 55, and are not tumorigenic in nude mice . [ 2 ]