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The term "backdoor pathway" was coined by Auchus in 2004 [25] and was described as 5α-reduction of 17α-hydroxyprogesterone (17OHP) which is a first step in a pathway that ultimately leads to the production of dihydrotestosterone (DHT). and defined as a route to DHT that: (1) bypasses conventional intermediates androstenedione (A4) and T; (2 ...
This route is called the "backdoor pathway". [64] The pathway can start from 17α-hydroxyprogesterone or from progesterone and can be outlined as follows (depending on the initial substrate): 17α-hydroxyprogesterone → 5α-pregnan-17α-ol-3,20-dione → 5α-pregnane-3α,17α-diol-20-one → androsterone → 5α-androstane-3α,17β-diol → ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands. [1] [4] Production of cortisol begins at week 8 of fetal ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [ 7 ] [ 8 ] [ 9 ] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen , i.e., it binds to the progesterone receptors .
Also involved into a backdoor pathway from 17α-hydroxyprogesterone to dihydrotestosterone by 3α-reduction of a metabolic intermediary, 17α-hydroxydihydroprogesterone, into another intermediary, 17α-hydroxyallopregnanolone. [21] May be involved in the pathophysiology of PCOS Tooltip polycystic ovary syndrome. [12]
5α-Pregnane-3α,17α-diol-20-one is a metabolite, an intermediate product within the androgen backdoor pathway [17] in which 17α-hydroxyprogesterone (17-OHP) is 5α-reduced and finally converted to 5α-dihydrotestosterone (DHT) without testosterone as a metabolic intermediate.
These findings indicate that CYP17A1 plays a role in the metabolism of this steroid through both hydroxylation and lyase reactions in the 11-oxygenated steroid backdoor pathway to androgens. [ 1 ] [ 6 ] This pathway is important for regulating adrenal and gonadal steroid hormone biosynthesis and can contribute to elevated levels of androgens in ...
The activity of this enzyme towards 3α-diol is important not only in the conventional pathways of androgen biosynthesis, but also in the androgen backdoor patthway. [ 21 ] [ 22 ] [ 23 ] [ 7 ] An important emzyme activity in humans is the transformation of the one of the most potent natural androgens, 5α-dihydrotestosterone into 3α-diol, a ...