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Conventional DMARDs are known to be the first-line treatment for rheumatoid arthritis. [9] Treatment can be a monotherapy or in combination with other anti-arthritic medications. Common DMARDs include oral methotrexate, leflunomide, or sulfasalazine. Conventional DMARDs have a slow onset of action and can take 2–3 months to exhibit effect. [9]
Sulfasalazine also appears to be most effective in the short-term treatment of rheumatoid arthritis. [120] Hydroxychloroquine, in addition to its low toxicity profile, is considered effective for treatment of moderate RA symptoms. [121] Agents may be used in combination, however, people may experience greater side effects.
Auranofin is used to treat rheumatoid arthritis.It improves arthritis symptoms including painful or tender and swollen joints and morning stiffness. [4] Auranofin is a safer treatment compared to the more common injectable gold thiolates (gold sodium thiomalate and gold thioglucose), but meta-analysis of 66 clinical trials concluded that it is somewhat less effective.
August 1950—An arthritis program was established within the National Institute of Arthritis and Metabolic Diseases under Public Law 81-692. May 1972—P.L. 92-305 renamed the institute the National Institute of Arthritis, Metabolism, and Digestive Diseases.
The European Rheumatoid Arthritis Surgical Society (ERASS) was founded in 1979. [17] Around the turn of the 21st century, focus for treatment of patients with rheumatic disease shifted, and pharmacological treatment became dominant, while surgical interventions became rarer. [18] [19]
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.
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