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A muscarinic acetylcholine receptor agonist, also simply known as a muscarinic agonist or as a muscarinic agent, is an agent that activates the activity of the muscarinic acetylcholine receptor. [1] The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation.
For example, the drug pirenzepine is a muscarinic antagonist (decreases the effect of ACh), which is much more potent at M 1 receptors than it is at other subtypes. The acceptance of the various subtypes proceeded in numerical order, therefore, earlier sources may recognize only M 1 and M 2 subtypes, [ citation needed ] while later studies ...
[3] [2] These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS. [ 1 ] [ 4 ] Chemicals in this family can act either directly by stimulating the nicotinic or muscarinic receptors (thus mimicking acetylcholine), or indirectly by inhibiting cholinesterase , promoting acetylcholine ...
The term "anticholinergic" is typically used to refer to antimuscarinics which competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agents do not antagonize the binding at nicotinic acetylcholine receptors at the neuromuscular junction, although the term is sometimes used to refer to agents which do so. [3] [5]
According to their site of actions, cholinergic blocking drugs can be classified into two general types — antimuscarinic and antinicotinic agents. [1] Antimuscarinic agents (also known as muscarinic antagonists), including atropine and hyoscine, block acetylcholine at the muscarinic acetylcholine receptors.
It should only contain pages that are agonists of cholinergic receptors or lists of agonists of cholinergic receptors, as well as subcategories containing those things (themselves set categories). Topics about agonists of cholinergic receptors in general should be placed in relevant topic categories .
The muscarinic acetylcholine receptor M 2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene. [5] Multiple alternatively spliced transcript variants have been described for this gene. [5] It is G i-coupled, reducing intracellular levels of cAMP.
12672 Ensembl ENSG00000180720 ENSMUSG00000040495 UniProt P08173 P32211 RefSeq (mRNA) NM_000741 NM_001366692 NM_007699 RefSeq (protein) NP_000732 NP_001353621 NP_031725 Location (UCSC) Chr 11: 46.38 – 46.39 Mb Chr 2: 91.76 – 91.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The muscarinic acetylcholine receptor M 4, also known as the cholinergic receptor, muscarinic 4 (CHRM4 ...