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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.
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Ukrainian President Volodymyr Zelenskyy warned allies that the defense of his nation is a litmus test for broader Western resolve, after Russia fired at least 117 missiles and drones in an ...
The second Phase III study with lixivaptan is the ALERT study. [15] The goal of this study is to investigate whether lixivaptan can be safely used in patients with ADPKD who were previously treated with tolvaptan, but who had to permanently discontinue tolvaptan therapy due to liver toxicity .
Kelce played in 15 last year, missing his first game due to injury since his rookie season, and garnered 984. Jahmyr Gibbs had just under 2,000 fewer votes than Kelce as the second-highest vote ...
Use cough drops or lozenges. Try a warm drink like hot water and lemon or tea. Stand in a steamy shower to let the humidity help soothe your lungs.
In medicine, diuretics are used to treat heart failure, liver cirrhosis, hypertension, influenza, water poisoning, and certain kidney diseases. Some diuretics, such as acetazolamide , help to make the urine more alkaline , and are helpful in increasing excretion of substances such as aspirin in cases of overdose or poisoning.