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Kasabach–Merritt syndrome (KMS), also known as hemangioma with thrombocytopenia, [1] is a rare disease, usually of infants, in which a vascular tumor leads to decreased platelet counts and sometimes other bleeding problems, [2] which can be life-threatening. [3] It is also known as hemangioma thrombocytopenia syndrome.
A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form, seen in infants, is an infantile hemangioma, known colloquially as a "strawberry mark", most commonly presenting on the skin at birth or in the first weeks of life.
Multidisciplinary clinical practice guidelines for the management of infantile hemangiomas were recently published. [42] Indications for treatment include functional impairment (i.e. visual or feeding compromise), bleeding, potentially life-threatening complications (airway, cardiac, or hepatic disease), and risk of long-term or permanent ...
Radiation treatment used for other medical conditions has been suggested to cause cavernous malformation in some patients. [16] Hemangioma tumors are a result of rapid proliferation of endothelial cells and pericytic hyperplasia, or the enlargement of tissue as a result of abnormal cell division pericytes. The pathogenesis of hemangioma is ...
With intracranial hemangiomas, hemorrhages are seen frequently. Since shrinkage of organs, otherwise known as involution, is found with cutaneous hemangioma, it can be said that involution can be used to help diagnose diffuse neonatal hemangiomatosis. Finally, there is no set therapy or treatment for intracranial hemangioma.
Targetoid hemosiderotic hemangioma manifests as a single, tiny, reddish-violaceous to brown targetoid lesion that can grow centrifugally in the acute phase is encircled by a hemorrhagic halo. [3] The halo may vanish in later phases, leaving just a central papule. [4] [5] There have been reports of certain cases without targetoid development. [6]
Vertebral hemangiomas or haemangiomas (VHs) are a common vascular lesion found within the vertebral body of the thoracic and lumbar spine. These are predominantly benign lesions that are often found incidentally during radiology studies for other indications and can involve one or multiple vertebrae.
Congenital hemangiomas are present and fully formed at birth, [5] and only account for 2% of the hemangiomas. They do not have the postnatal phase of proliferation common to infantile hemangiomas. [6] There are two main variants of congenital hemangioma: non-involuting, and rapidly involuting (beginning in the first year of life). [6]