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Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. [5] This includes aspergillosis , candidiasis , coccidioidomycosis , histoplasmosis , penicilliosis , and infections by Scedosporium or Fusarium . [ 5 ]
Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which fluconazole is not. The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits the fungal-mediated synthesis of ergosterol .
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. [ 7 ] [ 8 ] It was approved for medical use in the European Union in October 2005, [ 6 ] and in the United States in September 2006.
A fungus ball in the lungs may cause no symptoms and may be discovered only with a chest X-ray, or it may cause repeated coughing up of blood, chest pain, and occasionally severe, even fatal, bleeding. [2] A rapidly invasive Aspergillus infection in the lungs often causes cough, fever, chest pain, and difficulty breathing. [citation needed]
Common examples of imidazoles include clotrimazole, econazole, miconazole, ketoconazole, while fluconazole, itraconazole, posaconazole and voriconazole fall under triazoles group. Both groups cause substantial damage in fungal membrane integrity by lowering ergosterol levels, along with the loss of cytoplasmic components , thus bringing similar ...
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Today's NYT Connections puzzle for Wednesday, January 8, 2025The New York Times
Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which fluconazole is not. It is also licensed for use in blastomycosis, sporotrichosis, histoplasmosis, and onychomycosis.