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Progesterone ⓘ (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. [1] [13] It belongs to a group of steroid hormones called the progestogens [13] and is the major progestogen in the body. Progesterone has a variety of important functions in the body.
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...
It opposes the effects of estrogens in various parts of the body like the uterus and also blocks the effects of the hormone aldosterone. [20] [29] In addition, progesterone has neurosteroid effects in the brain. [20] Progesterone was first isolated in pure form in 1934. [30] [31] It first became available as a medication later that year.
Autoimmune progesterone dermatitis is a rare condition that can occur when progesterone rises during a woman's menstrual cycle. It can cause a physical reaction that may present differently ...
During menopause, the body stops producing two hormones integral to menstruation and pregnancy: estrogen and progesterone. Estrogen deficiency, in particular, leads to many of the symptoms ...
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
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