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The uterus and endometrium was for a long time thought to be sterile. The cervical plug of mucosa was seen to prevent the entry of any microorganisms ascending from the vagina. In the 1980s this view was challenged when it was shown that uterine infections could arise from weaknesses in the barrier of the cervical plug.
Endometrial tissue most often grows on or around reproductive organs such as the ovaries and fallopian tubes, on the outside surface of the uterus, or on the tissues surrounding the uterus and the ovaries . [3] It can also grow on other organs in the pelvic region like the bowels, stomach, bladder, or the cervix. [10]
In endometriosis, some endometrial-like tissue is found in other parts of the body; most often the pelvis and abdomen, the central nervous system, the nasal passages, skin and thorax. At these other 'ectopic' sites, endometrium tissue still responds to hormones with normal cyclical changes - bleeding roughly every 28 days. [medical citation needed]
When the endometrial mucous membrane is found outside of the uterus in places such as the ovaries, it causes chronic pelvic pain with intercourse and menstrual cycles. Endometriomas can produce a toxic environment by producing estrogen, cytokines, interleukins, and other inflammatory substances, that could damage healthy endometriomal tissue.
The endometrial biopsy is a medical procedure that involves taking a tissue sample of the lining of the uterus. The tissue subsequently undergoes a histologic evaluation which aids the physician in forming a diagnosis.
An endometrial polyp or uterine polyp is a mass in the inner lining of the uterus. [1] They may have a large flat base or be attached to the uterus by an elongated pedicle (pedunculated). [2] [3] Pedunculated polyps are more common than sessile ones. [4] They range in size from a few millimeters to several centimeters. [3]
The diagnosis of adenomyosis is through a pathologist microscopically examining small tissue samples of the uterus. [4] These tissue samples can come from a uterine biopsy or directly following a hysterectomy. Uterine biopsies can be obtained by either a laparoscopic procedure through the abdomen or hysteroscopy through the vagina and cervix ...
Hormones produced in early pregnancy stimulate the uterine glands to secrete a number of substances to give nutrition and protection to the embryo and fetus, and the fetal membranes. [1] These secretions are known as histiotroph, alternatively histotroph, and also as uterine milk. [1] [2] Important uterine milk proteins are glycodelin-A, and ...