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The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).
[8] [10] [11] As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. [9] The extracellular domain of LRP1 is the alpha-chain, which comprises four ligand -binding domains (numbered I-IV) containing two, eight, ten, and ...
Apo-E interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing of triglyceride-rich lipoproteins. [7] In peripheral tissues, Apo-E is primarily produced by the liver and macrophages , and mediates cholesterol metabolism.
A ligand binding assay (LBA) is an assay, or an analytic procedure, which relies on the binding of ligand molecules to receptors, antibodies or other macromolecules. [1] A detection method is used to determine the presence and amount of the ligand-receptor complexes formed, and this is usually determined electrochemically or through a fluorescence detection method. [2]
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [1] Naturally occurring antibodies typically only target one antigen. BsAbs can be manufactured in several structural formats.
In the last few years, we've all gotten pretty comfortable. Many of us have sacrificed style for that I'm-still-at-home-in-my-sweats sensation.
A federal appeals court blocked Nasdaq rules to increase boardroom diversity, saying that the Securities and Exchange Commission did not have the authority to approve them. Wednesday’s ruling ...
The Cocoon by Sealy is an excellent cooling mattress ideal for sleepers who run hot or live in warmer climates. The Cocoon Chill usually costs over $1,000, but during Black Friday, it's down to ...