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HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. [8]
These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [12] Such proteins modulate phenotypes such as cell migration, adhesion, and proliferation. Activation of the receptor is important for the innate immune response in ...
The human ERBB3 gene is located on the long arm of chromosome 12 (12q13). It is encoded by 23,651 base pairs and translates into 1342 amino acids. [5]During human development, ERBB3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. [6]
Cardiac physiology or heart function is the study of healthy, unimpaired function of the heart: involving blood flow; myocardium structure; the electrical conduction system of the heart; the cardiac cycle and cardiac output and how these interact and depend on one another.
107221 Ensembl ENSG00000186188 ENSMUSG00000054200 UniProt Q5NUL3 Q7TMA4 RefSeq (mRNA) NM_001195755 NM_181745 NM_181748 RefSeq (protein) NP_001182684 NP_859529 NP_861413 Location (UCSC) Chr 10: 93.57 – 93.6 Mb Chr 19: 38.09 – 38.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein ...
Currently, human clinical trials are being conducted to study the effectiveness of gene therapy with VEGF-A in restoring blood flow and function to areas of the heart that have severely restricted blood flow. [31] [32] [33] So far, this type of therapy has proven both safe and beneficial. [33] [34]
BUENOS AIRES (Reuters) -An Argentine court dismissed aggravated rape charges against French international rugby players Hugo Auradou and Oscar Jegou on Tuesday, drawing a line under a dark period ...
The two receptor pathways are named as a result of their role in mediating cell signals by inducing the phosphorylation of specific tyrosines. This in turn initiates the binding and activation of downstream intracellular enzymes , a process known as cell signaling.
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