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Status epilepticus is a life-threatening medical emergency, particularly if treatment is delayed. [1] Status epilepticus may occur in those with a history of epilepsy as well as those with an underlying problem of the brain. [2] These underlying brain problems may include trauma, infections, or strokes, among others.
As is the case with other non-convulsive status epilepticus forms, CPSE is dangerously underdiagnosed. [3] This is due to the potentially fatal yet veiled nature of the symptoms. Usually, an electroencephalogram, or EEG, is needed to confirm a neurologist's suspicions.
This rare epilepsy has a wide age range of presentation (from the first year of life through the early teens). This epilepsy is characterized by absence seizures concurrent with myoclonic jerks, typically occurring several times daily. The genetics of this disorder have not been delineated. Seizures from this disorder often cease within 5 years.
Risk factors for SUDEP include nocturnal generalized tonic-clonic seizures, seizures, sleeping alone and medically intractable epilepsy. [199] In the United Kingdom, it is estimated that 40–60% of deaths are possibly preventable. [26] In the developing world, many deaths are due to untreated epilepsy leading to falls or status epilepticus. [19]
Status epilepticus is a seizure "lasting longer than 30 minutes or a series of seizures without return to the baseline level of alertness between seizures." [ 12 ] Epilepsia partialis continua is a rare type of focal motor seizure, commonly involving the hands or face , which recurs with intervals of seconds or minutes, lasting for extended ...
Some clinical factors that are thought to be predictive of DRE include the female sex, focal epilepsy, developmental delay, status epilepticus, earlier age of onset of epilepsy, neurological deficits, having an abnormal EEG and/or imaging findings, genetic predisposition, association with the ABCB1 gene, and inborn errors of metabolism.
Marinus Pharmaceuticals Inc (NASDAQ: MRNS) expects data from the RAISE Phase 3 trial of ganaxolone in refractory status epilepticus in 2H of 2023. Earlier data from the trial was expected in 2H of ...
In particular, the GABA agonists vigabatrin and tiagabine are used to induce, not to treat, absence seizures and absence status epilepticus. [30] Similarly, oxcarbazepine, phenytoin, phenobarbital, gabapentin, and pregabalin should not be used in the treatment of absence seizures because these medications may worsen absence seizures. [26]
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