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T RM cells develop from circulating effector memory T cell precursors in response to antigen. The main role in formation of T RM cells has CD103 and expression of this integrin is dependent on the cytokine TGF-β. CD8 + effector T cells that lack TGF-β fail to upregulate CD103, and subsequently do not differentiate into T RM cells.
In other projects Wikidata item; Appearance. ... (IATA code TRM) Science and technology ... T RM cell or tissue-resident memory T cell, ...
Unlike the naive B cells involved in the primary immune response the memory B cell response is slightly different. The memory B cell has already undergone clonal expansion , differentiation and affinity maturation , so it is able to divide multiple times faster and produce antibodies with much higher affinity (especially IgG ).
The Executive Board provides the strategic direction of research at the TRM. Expertise and scientific support is given by the Internal Advisory Board which includes experts of science, senior scientists, researchers and entrepreneurs. TRM Leipzig promotes application-oriented and interdisciplinary research projects in four areas:
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