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Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8] It is used either by mouth or injection into a muscle. [8] Hydroxyzine works by blocking the effects of histamine. [9]
Hydroxyzine doesn't act on u-opioid receptors, and the vast majority of anecdotal subjective information (pretty much the only avaliable information on how recreational drugs feel) indicates that hydroxyzine is not "fun" and does not feel like an opiate or even a GABA agonist (benzodiazepine, barbituate, ethanol, meprobamate, carisoprodol, etc ...
If you are experiencing nasal congestion, a decongestant (like Sudafed) may work better for you. On the other hand, if you have chest congestion and need to loosen and thin mucus, an expectorant ...
Medication for Anxiety: A Complete Guide. As you probably know from personal experience, anxiety can be a lot of things — a cause of insomnia, a roadblock to living your best life or a demon you ...
Hydroxyzine (Atarax) is an antihistamine originally approved for clinical use by the FDA in 1956. Hydroxyzine has a calming effect which helps ameliorate anxiety. Hydroxyzine efficacy is comparable to benzodiazepines in the treatment of generalized anxiety disorder. [41]
These compounds are structurally related to the ethylenediamines and the ethanolamines, and produce significant anticholinergic adverse effects with the exception of hydroxyzine, which has low to no affinity for muscarinic acetylcholine receptors and therefore produces negligible anticholinergic side-effects. [16]
H 1-antihistamines work by binding to histamine H 1 receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary nucleus in the brain. Antihistamines that target the histamine H 1-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing).
A 10 mg dose of cetirizine equals about a 30 mg dose of hydroxyzine in terms of peripheral antihistamine effect.) [31] PET studies with antihistamines have found that brain H 1 receptor occupancy of more than 50% is associated with a high prevalence of somnolence and cognitive decline, whereas brain H 1 receptor occupancy of less than 20% is ...
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