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The most common side effects are gastrointestinal (everyone’s favs: diarrhea, bloating, stomach pain, gas, indigestion and constipation). These affect up to 30 percent of metformin users.
Both metformin and Ozempic can have positive impacts on weight management, ... Other possible side effects can include: Dizziness. Fatigue. Headaches. ... reviewed all the risks and side effects ...
Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is uncertain. [125] [126] [127] Due to its effect on GLUT4 and AMPK, metformin has been described as an exercise mimetic. [128] [129]
These all work in different ways to lower blood sugar. Metformin is one of the most common first-line medications for type 2 diabetes. Side effects of diabetes medications can include weight loss.
Fatigue may be a side effect of certain medications (e.g., lithium salts, ciprofloxacin); beta blockers, which can induce exercise intolerance, medicines used to treat allergies or coughs, [41] and many cancer treatments, particularly chemotherapy and radiotherapy. Use of benzodiazepines has been found to correlate with higher fatigue. [40]
They work best with patients over 40 years old who have had diabetes mellitus for under ten years. They cannot be used with type 1 diabetes, or diabetes of pregnancy. They can be safely used with metformin or glitazones. The primary side-effect is hypoglycemia, which appears to happen more commonly with sulfonylureas than with other treatments ...
Prepare for potential side effects. Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can reduce the risk.
Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus: [4] [6] [7] it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.