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The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
While both types of antipsychotic drugs are effective, the main differences are that atypical ones generally have fewer side effects compared to typical ones. These side-effects may include the onset of extrapyramidal motor symptoms which in the long term may cause a condition called tardive dyskinesia , which involves involuntary movements of ...
Find out what typical and atypical antipsychotics are, what they are used for, how they work, and their potential risks and benefits.
The latter have a greater degree of anticholinergic and antihistaminergic activity, which can counteract dopamine-related side-effects. [179] Atypical antipsychotic drugs have a similar blocking effect on D 2 receptors; however, most also act on serotonin receptors, especially 5-HT 2A and 5-HT 2C receptors. Both clozapine and quetiapine appear ...
A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious than olanzapine and risperidone; produce fewer movement related side effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and ...
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [7] It is used primarily to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Antipsychotics by class Generic name Brand names Chemical class ATC code ... Atypical antipsychotics; Amoxapine: Asendin, Asendis, Defanyl, Demolox: dibenzoxazepine: