Search results
Results from the WOW.Com Content Network
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
An early life stage (ELS) test is a chronic toxicity test using sensitive early life stages like embryos or larvae to predict the effects of toxicants on organisms. [1] ELS tests were developed to be quicker and more cost-efficient than full life-cycle tests, taking on average 1–5 months to complete compared to 6–12 months for a life-cycle test.
U.S. Army Public Health Center Toxicology Lab technician assessing samples. Toxicology testing, also known as safety assessment, or toxicity testing, is the process of determining the degree to which a substance of interest negatively impacts the normal biological functions of an organism, given a certain exposure duration, route of exposure, and substance concentration.
Toxicology tests (14 P) ... Developmental toxicity; Dioxin Reassessment Report; Dose (biochemistry) ... Poison laboratory of the Soviet secret services; Poisoning;
Earthworm, Acute Toxicity Tests 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test 209: Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation) 210: Fish, Early-life Stage Toxicity Test 211: Daphnia magna Reproduction Test 212: Fish, Short-term Toxicity Test on Embryo and Sac-Fry Stages 213: Honeybees ...
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.
From the 1940s to the 1960s, animal bioassays were primarily used to test the toxicity and safety of drugs, food additives, and pesticides. [11] Beginning in the late 1960s and 1970s, reliance on bioassays increased as public concern for occupational and environmental hazards increased. [11]
In 2007, the National Research Council (NRC) released the report "Toxicity Testing in the 21st Century: A Vision and a Strategy", [41] that charted a long-range strategic plan for transforming toxicity testing. The major components of the plan include the use of predictive, high-throughput cell-based assays (of human origin) to evaluate ...