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Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. OPA is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV).
JSRV is the virus that is the cause of the contagious lung tumors in sheep called ovine pulmonary adenocarcinoma (OPA). The disease has also been called "jaagsiekte", after the Afrikaans words for "chase" (jaag) and "sickness" (siekte), to describe the respiratory distress observed in an animal out of breath from being chased, indicating the breathing difficulty experienced by infected sheep.
MeSH C22.836.583 – nairobi sheep disease MeSH C22.836.660 – pneumonia, progressive interstitial, of sheep MeSH C22.836.715 – pulmonary adenomatosis, ovine
Nairobi sheep disease orthonairovirus (NSDV) infection; orf, also known as contagious ecthyma, contagious pustular dermatitis, infectious labial dermatitis, thistle disease, sore mouth, or scabby mouth; ovine encephalomyelitis (louping ill) ovine progressive pneumonia (OPP) ovine pulmonary adenocarcinoma
In sheep, the disease is also called "circling disease". [4] The most obvious signs for the veterinarians are neurological, especially lateral deviation of the neck and head, opisthotonus or emprosthotonus. Other signs comprises compulsive movements of the lips, facial and masticatory muscles, with food staying in mouth.
Tumors form in nose and are contagious. ENTV targets the respiratory system in ovine, specifically the upper-airway epithelial cells. [6] Oncogenesis occurs in the nasal turbinate cells [8] A typical oncogenic virus will cause a mutation in a host cell, causing the transformation of host cells from a protooncogene into an oncogene.
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The muscles of respiration are the muscles that contribute to inhalation and exhalation, by aiding in the expansion and contraction of the thoracic cavity. The diaphragm and, to a lesser extent, the intercostal muscles drive respiration during quiet breathing. The elasticity of these muscles is crucial to the health of the respiratory system ...