Search results
Results from the WOW.Com Content Network
Similarly, the same sequences in the fugu genome have 68% identity to human UCEs, despite the human genome only reliably aligning to 1.8% of the fugu genome. [4] Despite often being noncoding DNA, [6] some ultraconserved elements have been found to be transcriptionally active, producing non-coding RNA molecules. [7]
Within a sequence, amino acids that are important for folding, structural stability, or that form a binding site may be more highly conserved. [17] [18] The nucleic acid sequence of a protein coding gene may also be conserved by other selective pressures. The codon usage bias in some organisms may restrict the types of synonymous mutations in a ...
The term "repeated sequence" was first used by Roy John Britten and D. E. Kohne in 1968; they found out that more than half of the eukaryotic genomes were repetitive DNA through their experiments on reassociation of DNA. [5] Although the repetitive DNA sequences were conserved and ubiquitous, their biological role was yet unknown.
Regulatory sequences are located at the extremities of genes. These sequence regions can either be next to the transcribed region (the promoter) or separated by many kilobases (enhancers and silencers). [8] The promoter is located at the 5' end of the gene and is composed of a core promoter sequence and a proximal promoter sequence.
UCbase is a database of ultraconserved sequences (UCRs or UCEs) that were first described by Bejerano, G. et al. [2] in 2004. They are highly conserved genome regions that share 100% identity among human, mouse and rat.
A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. These sequences are of interest for their potential to regulate gene production. [1] CNSs in plants [2] and animals [1] are highly associated with transcription factor binding sites and other cis-acting regulatory elements.
Discover the best free online games at AOL.com - Play board, card, casino, puzzle and many more online games while chatting with others in real-time.
The repeats are normally a few hundred base pairs in length. These sequences constitute about 13% of the human genome [2] with the specific Alu sequence accounting for about 10%. LINE: Long interspersed sequences. The repeats are normally several thousand base pairs in length. These sequences constitute about 21% of the human genome. [2]