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Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
Thiazides combined with potassium citrate, increased water intake and decreased dietary oxalate and sodium can slow or even reverse the formation of calcium-containing kidney stones. [18] High-dose therapy with the thiazide-like diuretic indapamide can be used to treat idiopathic hypercalcinuria (high urine calcium with unknown cause). [19]
For example, up to 98% of small stones (less than 5 mm (0.2 in) in diameter) may pass spontaneously through urination within four weeks of the onset of symptoms, [7] but for larger stones (5 to 10 mm (0.2 to 0.4 in) in diameter), the rate of spontaneous passage decreases to less than 53%. [85]
[4] [2] It is also used to prevent calcium-based kidney stones. [2] It is taken by mouth. [2] Effects generally begin within three hours and last for up to three days. [2] Long-term treatment with chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke. [5]
Treatments depend on the patient, the type of kidney stone and several other factors. These include: Surgical intervention. Some patients may need surgery to remove kidney stones or to help them pass.
Triamterene directly blocks the epithelial sodium channel [4] (ENaC) on the lumen side of the kidney collecting tubule. [5]: 127 Other diuretics cause a decrease in the sodium concentration of the forming urine due to the entry of sodium into the cell via the ENaC, and the concomitant exit of potassium from the principal cell into the forming urine.
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related to: hydrochlorothiazide dosage for kidney stones chart mm to inches