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Particularly controversial was the work of Harvard neurosurgeon Vernon Mark and psychiatrist Frank Ervin, who wrote a book, Violence and the Brain, in 1970. [1] The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in 1977 endorsed the continued limited use of psychosurgical procedures.
The San Antonio Contraceptive Study was a clinical research study published in 1971 about the side effects of oral contraceptives. Women coming to a clinic in San Antonio, Texas to prevent pregnancies were not told they were participating in a research study or receiving placebos. Ten of the women became pregnant while on placebos. [183] [184 ...
As ineffective treatment was given to the subjects, two-thirds of the group had died by the end of the 40-year experiment. A leak in 1972 led to cessation of the study and severe legal ramifications. It has been widely regarded as the "most infamous biomedical research study in U.S. history". [62]
Joachim Boldt (Germany), an anesthesiologist formerly based at the Justus Liebig University Giessen, was stripped of his professorship and criminally investigated for forgery in his research studies. [17] As of 2024, Boldt has had 220 of his research publications retracted, and 10 others have received an expression of concern. [18] [19]
While most major controversies about unethical research were focused on biomedical sciences, there were also controversies involving behavioral, psychological, and sociological experiments such as: the Milgram obedience experiment, Stanford prison experiment, Tearoom Trade study, and others.
The 40-year Tuskegee Study was a major violation of ethical standards [12] and has been cited as "arguably the most infamous biomedical research study in U.S. history." [ 15 ] Its revelation led to the 1979 Belmont Report and to the establishment of the Office for Human Research Protections (OHRP) [ 16 ] and federal laws and regulations ...
National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research was the first public national body to shape bioethics policy in the United States. Formed in the aftermath of the Tuskegee Experiment scandal, the commission was created in 1974 as Title II of the National Research Act .
The Belmont Report is a 1978 report created by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.Its full title is the Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research, Report of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.