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  2. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  3. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  4. Alcohol is not good for us. 5 tips to stay safe(r) if you drink

    www.aol.com/drink-not-drink-5-tips-142139741.html

    Study participants who were given alcoholic drinks received a specific amount of alcohol, based on sex and weight, that would get them to a 0.06% blood alcohol level, Kilmer said.

  5. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  6. Is red wine good for your heart? Consider this wisdom from a ...

    www.aol.com/red-wine-good-heart-consider...

    For someone to get adequate levels of resveratrol, London said in the video, "you would have to drink a huge amount of red wine – and this amount of alcohol would clearly outweigh any benefits ...

  7. Grapefruit–drug interactions - Wikipedia

    en.wikipedia.org/wiki/Grapefruit–drug_interactions

    The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [ 9 ] [ 10 ] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [ 11 ]

  8. The Worst Foods to Eat When Taking Wegovy for Weight Loss - AOL

    www.aol.com/worst-foods-eat-taking-wegovy...

    Keep a food log to track your food choices and see if they correlate with any symptoms. Make healthier swaps while preparing meals. For example, instead of using butter when cooking, opt for olive ...

  9. CYP3A4 - Wikipedia

    en.wikipedia.org/wiki/CYP3A4

    The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...