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Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. [4] They are often used for the treatment of hypertension and edema secondary to congestive heart failure , liver cirrhosis , or chronic kidney disease .
Thiazide diuretics also increase calcium reabsorption at the distal tubule. By lowering the sodium concentration in the tubule epithelial cells, thiazides indirectly increase the activity of the basolateral Na + /Ca 2+ antiporter to maintain intracellular Na + level, facilitating Ca 2+ to leave the epithelial cells into the renal interstitium.
A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does not have the chemical properties of a thiazide, lacking the benzothiadiazine molecular structure. Examples include metolazone, chlorthalidone, and indapamide. [1]
Tesla's stock price reached $420 on Wednesday afternoon, which elicited responses from social media users and the company's CEO, Elon Musk. "As foretold in the prophecy," Musk wrote in an X post ...
Over a 45-years span — between 1975 and 2020 — improvements in cancer screenings and prevention strategies have reduced deaths from five common cancers more than any advances in treatments ...
Amy Adams' mom Kathryn has always been an active multitasker.. The Nightbitch actress, 50, said on Live with Kelly and Mark that her mother not only raised seven children but did so while ...
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George Clooney is paying tribute to his former “Ocean's Eleven” costar, "gentle soul" Scott L. Schwartz who has died at the age of 65. “I’m sorry to hear that Scott is gone,” Clooney, 63 ...